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Phentermine (Adipex)

Phentermine is a prescription medication that can help you lose weight. While doctors aren’t exactly sure how it works, they do know that it suppresses appetite and increases your heart rate, which may lead to faster burning of fat.

Phentermine was approved for use in the United States in During the s, doctors started combining this medicine with other weight loss medicines. This combination was called fen-phen. While it was highly effective for weight loss, it also came with devastating cardiovascular side effects. The product was taken off the market in , and many major lawsuits followed.

Who cannot take Phentermine (Adipex)?

As phentermine is a stimulant of the nervous system, there are some people who should not take it. This includes those suffer from:

  • anxiety or agitation
  • glaucoma
  • heart conditions
  • high blood pressure
  • hypothyroidism

Phentermine can be dangerous for those who suffer from these conditions because it raises blood pressure and heart rate, which can lead to heart damage, heart attacks, and strokes. You must inform your doctor if you suffer from any of these conditions. You may still use the medicine, but your doctor will make the appropriate decisions about dosage or whether you need to get other conditions under control before starting this medicine.

This medicine should also not be taken by those who have used an MAO inhibitor (antidepressant) in the previous two weeks as there’s a risk for a severe interaction.

You should also not take this medicine if you are already taking other medications, including non-prescription diet pills, for weight loss.

Dosage information

Doctors usually prescribe Phentermine for up to 12 weeks. After this time, the medicine may lose its effectiveness, so you won’t lose any more weight. This medicine should be used in conjunction with a healthy diet and exercise to lose weight.

It’s also important to note that you should take exactly how much your doctor tells you to—taking more will not help you lose more weight or lose it faster, but it could increase the side effects that you experience.

Phentermine is usually prescribed as a single dose of up to mg in the morning or three doses of 8mg spread throughout the day. If you’re prescribed a single dose, you’ll take it before you eat breakfast or a couple of hours after. If you are taking multiple doses per day, you’ll take it half an hour before meals.

What if I miss a dose?

If you forget to take your medicine, you should take it as soon as remember, unless it’s time for the next dose or it’s late in the day. You should not take two doses at the same time.

Phentermine side effects

This weight loss medicine may produce both minor and serious side effects. Some of the most common side effects include:

Minor Side Effects

Serious Side Effects

Dizziness and nausea

Chest pain

Dry mouth

Difficulty breathing


Rapid heartbeat

Itchiness and rash

Swelling in your extremities

Stomach upset, including diarrhea and constipation

Tremors and restlessness


You should discuss all side effects you experience with your doctor, but you should immediately seek help if you are plagued by any of the serious side effects listed above.

How much weight will I lose?

Weight loss depends on many factors, including your age and gender. The most important factor concerns how much you eat; that is, how many calories you consume. In order to lose weight, you have to consume fewer calories than you burn.

Phentermine helps you lose weight by reducing your appetite: You won’t eat as much, so you’ll burn more calories than you take it. Most patients can expect a 5% reduction in body weight a week course. However, some individuals have experienced as much as 10% weight loss. If you weight lbs, 5% is equal to a weight loss of lbs and 10% is equal to 25 lbs.

To experience better weight loss, doctors recommend consuming a low-calorie diet and incorporating exercise into your daily routine. Some doctors may also prescribe the anti-seizure medicine topiramate for better results. Studies have shown that this medicine can also suppress the appetite, so you may experience better weight loss when the two are combined.


Top-Selling Diet Drug Phentermine Is Cheap and Easy to Get

Judi Wade said the doctor who prescribed phentermine for her weight loss rarely weighed her or took her blood pressure.

The Food and Drug Administration has approved several new weight-loss drugs in recent years, but the best-selling diet pill in America isn’t among them.

That title belongs to phentermine, a generic drug that has been around for decades and has managed to hold its own despite the arrival of new competitors.

The drug is viewed as effective and relatively safe to help jump-start diets in patients who are obese. However, phentermine — a stimulant that can give users an inexpensive high — has a long history of misuse. It has also frequently flown under the radar of regulators, who tend to focus their resources on deadlier drugs like opioid painkillers.

Adding to the concern is the fact that many doctors have an incentive to recommend it: Phentermine is a mainstay of weight-loss clinics nationwide, prescribed by physicians who profit by selling the pill to patients. Fans of the drug trade tips on social media sites and websites like, where users refer to each other as “phrends” and share the names of doctors who will prescribe it with few questions asked.

“There’s just not enough resources to shut down everybody that should be shut down,” said Carmen A. Catizone, executive director of the National Association of Boards of Pharmacy.

Phentermine’s staying power has persisted despite F.D.A. approval of four new weight-loss products since , all of which arrived with great fanfare but whose sales have so far failed to live up to expectations.

Phentermine — approved in and now made by several manufacturers — commands 80 percent of the market for diet drugs, according to IMS Health, which tracks prescription drug use.

Phentermine is inexpensive, often going for about $30 for a month’s supply. The newer drugs, by contrast, can cost hundreds of dollars a month and are sometimes not covered by insurance.

In the s, phentermine was used as one half of the combination treatment known as fen-phen, the weight-loss sensation that was later discovered to cause heart-valve problems in some patients. The other two drugs commonly used in the treatment, fenfluramine and dexfenfluramine, were withdrawn from the market. Phentermine, which was not linked to the heart problem, was allowed to remain available.

Because phentermine was approved at a time when drug companies weren’t held to the same standards as new drugs, little is known about the drug through formal trials.

Still, patients who take phentermine must be screened, because the drug can intensify existing heart problems and it can be abused by people with eating disorders. Users often develop a tolerance and require higher doses. It is approved only for short-term use in obese patients, in conjunction with a plan that includes exercise and a healthy diet.

But many doctors prescribe phentermine to patients for long-term use and argue that the practice is safe. “It’s lamentable that it’s not being used more widely, because it really does work,” said Dr. Ed J. Hendricks, who runs the Hendricks for Health weight-loss clinic in Sacramento, Calif. He has conducted research on phentermine use and concluded that it is not addictive. Others said phentermine could be misused.

“It’s sort of like a cheap speed,” said C. Richard Allen, director of the Georgia Drugs and Narcotics Agency, which oversees the use of controlled substances like phentermine.

Judi Wade, a former phentermine user who lives on the East End of Long Island, credits the drug with helping her reduce her weight to pounds from pounds.

Ms. Wade, who is 50 and unemployed, bought the drugs from a doctor who advertised his services in a newspaper. He charged $ for 60 pills, she said, and offered discounts for buying in bulk.

Ms. Wade said the physician, Dr. Samir Mostafa, rarely weighed her or took her blood pressure.

She said she stopped taking phentermine after about a year because she didn’t like the way it made her feel.

In , New York State’s Board of Professional Medical Conduct stripped Dr. Mostafa of his ability to practice medicine, saying he had failed to properly report his dispensing activities and had been inappropriately prescribing the drug. Amy T. Kulb, a lawyer for Dr. Mostafa, declined to comment.

Among the state’s claims was that Dr. Mostafa had prescribed “excessive amounts” of phentermine to another patient, whose blood pressure he also failed to monitor. The woman, state regulators said, was 5-foot-7 and weighed 93 pounds.


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